Drug-induced renal injury in neonates: challenges in clinical practice and perspectives in drug development
Introduction: Acute kidney injury (AKI) is frequently diagnosed in the neonatal population, especially in those admitted to intensive care units, and poses several challenges for clinicians mainly because of difficulties in timely identification of renal impairment and the need to administer drugs with potential nephrotoxicity. In this context, research on biomarkers is growing for their implication in the early detection of renal damage and their higher sensitivity in monitoring renal activity, but also as an important tool for drug development. Areas covered: We described the tools currently used to detect renal damage in neonatal settings, their limits and applicability, as well as the role of drugs on renal toxicity occurrence. Subsequently, we discuss current knowledge on new biomarkers for the detection of kidney injury and drug-induced kidney injury in neonates, and the qualification programs developed by regulatory agencies for biomarkers intended as tools in drug development. Expert opinion: Some molecules are emerging as potential biomarkers for early detection of AKI: promising data has demonstrated higher sensitivity and accuracy compared with tools currently used in the clinical setting. In addition, novel techniques (e.g. high power magnetic resonance imaging) to assess long-term consequences of AKI in neonates are in early steps of development.
|Keywords||Acute kidney injury, biomarkers, drug-induced renal injury, neonates|
|Persistent URL||dx.doi.org/10.1080/17425255.2017.1290081, hdl.handle.net/1765/99903|
|Journal||Informa Health Care|
Girardi, A, Raschi, E, Galletti, S, Allegaert, K.M, Poluzzi, E, & de Ponti, F. (2017). Drug-induced renal injury in neonates: challenges in clinical practice and perspectives in drug development. Informa Health Care (Vol. 13, pp. 555–565). doi:10.1080/17425255.2017.1290081