2014-01-15
Fetal and Infant Origins of Childhood Asthma: The Generation R Study
Publication
Publication
Foetale en vroeg postnatale oorzaken van astma op de kinderleeftijd: Het Generation R onderzoek
Abstract
Asthma is a chronic inflammatory disorder of the airways. Accumulating evidence suggest that childhood asthma has at least part of its origins in fetal life and infancy. The developmental plasticity hypothesis suggests that adverse exposures in early life lead to developmental adaptations of various organ systems, including of the respiratory tract to enhance survival in the short term. We observed that rapid infant growth is, independent of fetal growth, associated with an increased risk of childhood asthma. Also maternal gestational weight gain and psychological distress were associated with increased risks. A longer duration and exclusive breastfeeding were associated with a reduced risk of childhood asthma.
| Additional Metadata | |
|---|---|
| , , , , , , , , , , | |
| J.C. de Jongste (Johan) , V.W.V. Jaddoe (Vincent) | |
| The general design of the Generation R Study was made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development (ZonMw), the Netherlands Organisation for Scientific Research (NWO), the Ministry of Health, Welfare and Sport and the Ministry of Youth and Families. Agnes Sonnenschein-van der Voort is the recipient of a European Respiratory Society Fellowship (STRTF 93-2012) and received a grant from the Ter Meulen Fund, Royal Netherlands Academy of Arts and Sciences (TMF2012/228). The work presented in this thesis was conducted at the Department of Paediatrics, Division of Paediatric Respiratory Medicine, the Generation R Study Group, and the Department of Epidemiology of the Erasmus Medical Center in Rotterdam, the Netherlands, and at the ALSPAC study, School of Social and Community Medicine, University of Bristol, United Kingdom. The printing of this thesis has been financial supported by the Erasmus University Rotterdam, the Generation R Study, Longfonds, and Stichting Astma Bestrijding. Further financial support for this dissertation was kindly provided by ALK-Abello BV, Boehringer Ingelheim BV, Chiesi Pharmaceuticals BV, Chipsoft BV, GlaxoSmithKline, Medela BV, Nutricia baby- en kindervoeding, and Thermo Fisher Scientific/IDD. | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/50263 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
|
van der Sonnenschein-Voort, A. (2014, January 15). Fetal and Infant Origins of Childhood Asthma: The Generation R Study. Retrieved from http://hdl.handle.net/1765/50263 |
|
| Additional Files | |
|---|---|
| 3914_Sonnenschein-van-der-Voort-Agnes-Maria-Mariamna.jpg Cover Image , 20kb | |
| Stellingen-Sonnenschein-van-der-Voort.pdf , 36kb | |
