The role of monocytes and monocyte-derived dendritic cells in type 1 diabetes mellitus and autoimmune thyroid disease
(De rol van monocyten en van monocyten afkomstige dendritische cellen in type 1 diabetes mellitus en auto-immuun schildklierziekten)
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Type 1 diabetes mellitus (DM1) and autoimmune thyroid disease (AITD) are organ specific autoimmune diseases in which the immune system is directed against the ß cells and the thyrocytes respectively. The etio-pathogenesis of organ-specific or endocrine autoimmune diseases is complex, polygenic and heavily dependent on various environmental influences. The exact etiology of these diseases remains to be clarified, the pathogenesis is strongly associated with autoimmune phenomena. None of current treatment approaches provide a cure, but represent replacement therapies.
Drexhage, Prof. Dr. H.A. (promotor)
Commission of the European Communities (grant no. MONODIAB QLRT-1999-00276)
Dutch Diabetes Foundation (grant no. 96.606)
Novo Nordisk Farma B.V.
ZWO, Netherlands Organization for Scientific Research NOW (ZonMW) (grant no. 903-40-193)
- dm 1 patients
- animal models
- dendritic cells
- type 1 diabetes
- t cells