The primary aim of the research described in this thesis was to gain more insight into host pathogen interaction between Staphylococcus aureus and the human host by specifically studying the IgG (subclass specific) humoral response against staphylococcal virulence factors in humans with different interactions with S. aureus, the kinetics of the production of several of these immune modulators during biofilm formation, and finally, by studying the production of biofilm in staphylococcal bacteremia to gain better understanding of persistence of bacteremia. When the immune system fails to clear an infection, clinicians use antibiotics to treat infections. The secondary aim of this thesis was, therefore, to find antibiotics with truly novel modes of action directed against infections with multi drug resistant ESKAPE pathogens.

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H.A. Verburgh , W.J.B. van Wamel (Willem)
Erasmus University Rotterdam
Department of Medical Microbiology and Infectious Diseases

Swierstra, J. (2017, June 20). Antibiotics and Host Responses in the Pathogenesis of Staphylococcus Aureus Infection. Retrieved from