The main aim of this thesis was to evaluate the efficacy of three phases of a treatment algorithm of inpatients with severe depression: phase I optimal antidepressant monotherapy (plasma level targeted dose imipramine or high-dose (375 mg/day) venlafaxine); phase II subsequent lithium addition in case of insufficient improvement of antidepressant monotherapy; phase Ill subsequent ECT in case of insufficient improvement of antidepressant-lithium treatment. Additionally, this thesis aims to further investigate predictors of antidepressant treatment response, i.e. early drug response, gender and menopausal status.

Severe depression, antidepressant, lithium, treatment algorithm, predictors of response
W.J.G. Hoogendijk (Witte) , T.K. Birkenhäger (Tom)
Erasmus University Rotterdam
Department of Psychiatry

Vermeiden, M. (2018, June 8). Efficacy of Antidepressant Treatment for Inpatients with Severe Depression. Erasmus University Rotterdam. Retrieved from