The main aim of this thesis was to evaluate the efficacy of three phases of a treatment algorithm of inpatients with severe depression: phase I optimal antidepressant monotherapy (plasma level targeted dose imipramine or high-dose (375 mg/day) venlafaxine); phase II subsequent lithium addition in case of insufficient improvement of antidepressant monotherapy; phase Ill subsequent ECT in case of insufficient improvement of antidepressant-lithium treatment. Additionally, this thesis aims to further investigate predictors of antidepressant treatment response, i.e. early drug response, gender and menopausal status.

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W.J.G. Hoogendijk (Witte) , T.K. Birkenhäger (Tom)
Erasmus University Rotterdam
Department of Psychiatry

Vermeiden, M. (2018, June 8). Efficacy of Antidepressant Treatment for Inpatients with Severe Depression. Retrieved from