The main aim of this thesis was to evaluate the efficacy of three phases of a treatment algorithm of inpatients with severe depression: phase I optimal antidepressant monotherapy (plasma level targeted dose imipramine or high-dose (375 mg/day) venlafaxine); phase II subsequent lithium addition in case of insufficient improvement of antidepressant monotherapy; phase Ill subsequent ECT in case of insufficient improvement of antidepressant-lithium treatment. Additionally, this thesis aims to further investigate predictors of antidepressant treatment response, i.e. early drug response, gender and menopausal status.

Additional Metadata
Keywords Severe depression, antidepressant, lithium, treatment algorithm, predictors of response
Promotor W.J.G. Hoogendijk (Witte) , T.K. Birkenhäger (Tom)
Publisher Erasmus University Rotterdam
ISBN 978-94-6299-894-0
Persistent URL hdl.handle.net/1765/105965
Citation
Vermeiden, M. (2018, June 8). Efficacy of Antidepressant Treatment for Inpatients with Severe Depression. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/105965