Scope and relevance of the thesis
This thesis focuses on the importance of cerebral perfusion pressure. The results are relevant to all patients in the perioperative setting, as all heath providers will receive practical tools that enable them to better guide patients in cases of deregulated cerebral perfusion.
Problem statement
Maintaining adequate cerebral perfusion in the perioperative setting is an important task for the anesthesiologist. However, this is sometimes difficult to achieve because the cerebral perfusion of the patient is influenced by different factors such as age, cerebrovascular diseases, positioning during surgery, anesthetic and vasoactive drugs, and artificial ventilation. Furthermore, cerebrovascular physiology and pathophysiology are still not fully understood as stated above.
Aim of the thesis
The aim of this thesis is to investigate important determinants of CPPe regulation and subsequently to provide recommendations on how to maintain adequate cerebral perfusion in the perioperative setting.

Additional Metadata
Keywords • Transcranial Doppler sonography, • Cerebral circulation, • Zero-flow pressure, • Critical closing pressure, • Cerebral perfusion pressure, • Resistance area product, • Hyperventilation, • Volatile aesthetics, • Argon, • Preeclampsia
Promotor R.J. Stolker (Robert) , A. Weyland (Andreas) , G.H. Visser (Gerhard)
Publisher Erasmus University Rotterdam
ISBN 978-94-6361-285-2
Persistent URL
Grüne, F. (2019, July 5). Importance Of The Effective Cerebral Perfusion Pressure. Erasmus University Rotterdam. Retrieved from