AIMS: D-dimer is a product of fibrinolysis. In clinical practice, D-dimer levels are commonly used to rule out venous thromboembolism. Antiplatelet drugs may influence D-dimer levels, potentially affecting the accuracy of this diagnostic tool. To evaluate the effect of antiplatelet drugs on D-dimer levels, we performed a systematic review and meta-analysis of all published articles on this topic (PROSPERO registration number CRD42017058932). METHODS AND RESULTS: We electronically searched EMBASE, MEDLINE Epub, Cochrane, Web of Science, and Google Scholar (100 top relevance) (last search on October 5, 2017). We included randomized controlled trials, cohort studies, and cross-sectional studies conducted in humans, with a drug exposure time of at least 7 days. Two reviewers independently selected eligible articles and extracted the data. Five controlled trials, 7 cohort studies, and 5 cross-sectional studies were finally included. Meta-analysis involving all 1117 participants showed no change in dimer levels (standardized mean difference: -0.015, 95% confidence interval, 0.182-0.151, P = 0.855). CONCLUSIONS: In conclusion, antiplatelet drugs do not seem to influence D-dimer levels.

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Keywords D-dimer, antiplatelet drugs, venous thromboembolism, meta-analysis
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Series VSNU Open Access deal
Journal Journal of Cardiovascular Pharmacology
Morelli, F, Schol-Gelok, S, Arends, L.R, Boersma, H, Kruip, M.J.H.A, Versmissen, J, & van Gelder, T. (2019). Effect of Antiplatelet Drugs on D-Dimer Levels: A Systematic Review and Meta-analysis. Journal of Cardiovascular Pharmacology, 73(6), 343–351. doi:10.1097/FJC.0000000000000670