Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings
BACKGROUND: Treatment of HCV with direct-acting antivirals has enabled the discussion of HCV eradication worldwide. Envisioning this aim requires implementation of mass screening in resource-limited areas, usually constrained by testing costs. METHODS: We validated a low-cost, rapid diagnosis test (RDT) for HCV in three different continents in 141 individuals. RESULTS: The HCV RDT showed 100% specificity and sensitivity across different samples regardless of genotype or viral load (in samples with such information, 90%). CONCLUSIONS: The HCV test validated in this study can allow for HCV screening in areas of need when properly used.
|Keywords||hepatitis C, rapid diagnostic test, resource-limited|
|Persistent URL||dx.doi.org/10.1093/inthealth/ihy101, hdl.handle.net/1765/118320|
Leathers, J.S. (James S.), Pisano, M.B. (Maria Belen), Re, V. (Viviana), van Oord, G.W, Sultan, A. (Amir), Boonstra, P.A, & Debes, J.D. (2019). Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings. International Health, 11(4), 314–315. doi:10.1093/inthealth/ihy101