Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies.

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Keywords Bayesian statistics, controlled human infection, hookworm, vaccine development
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Series VSNU Open Access deal
Journal The Journal of Infectious Diseases
Note Corresponding author affiliated with LUMC
Hoogerwerf, M.-A. (Marie-Astrid), Coffeng, L.E, Brienen, E.A.T, Janse, J.J. (Jacqueline J.), Langenberg, M.C.C. (Marijke C C), Kruize, Y.C.M. (Yvonne C M), … Roestenberg, M. (2019). New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections. The Journal of Infectious Diseases, 220(6), 1044–1048. doi:10.1093/infdis/jiz218