2019-08-09
New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections
Publication
Publication
The Journal of Infectious Diseases , Volume 220 - Issue 6 p. 1044- 1048
Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies.
| Additional Metadata | |
|---|---|
| , , , | |
| doi.org/10.1093/infdis/jiz218, hdl.handle.net/1765/119284 | |
| VSNU Open Access deal | |
| The Journal of Infectious Diseases | |
| Organisation | Department of Public Health |
|
Hoogerwerf, M.-A. (Marie-Astrid), Coffeng, L., Brienen, E., Janse, J.J. (Jacqueline J.), Langenberg, M.C.C. (Marijke C C), Kruize, Y.C.M. (Yvonne C M), … Roestenberg, M. (2019). New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections. The Journal of Infectious Diseases, 220(6), 1044–1048. doi:10.1093/infdis/jiz218 |
|