Biomarkers have become an integral part of the clinical decision-making process of clinicians dealing with febrile children. C-reactive protein, procalcitonin and white blood cell count are probably the most studied ones. Crucial to using biomarkers is the understanding of how a test result will alter post-test probabilities and then impact on clinical decision making. Improved analytical and computational platforms have enabled the next generation of advanced biomarker discovery studies. Promising combinations of candidate biomarkers for a diverse spectrum of febrile illnesses, such as viral and bacterial infections, have been identified using proteomics, RNA gene expression and metabolomics.

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Keywords biomarker, C-reactive protein, procalcitonin, serious blood stream infection
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Journal The Pediatric Infectious Disease Journal
Stol, K., Nijman, R.G., van Herk, W., & van Rossum, A.M.C. (2019). Biomarkers for Infection in Children: Current Clinical Practice and Future Perspectives. The Pediatric Infectious Disease Journal, 38(6), S7–S13. doi:10.1097/inf.0000000000002318