Mass spectrometry-based techniques can be applied to investigate collagen with respect to identification, quantification, supramolecular organization, and various post-translational modifications. The continuous interest in collagen research has led to a shift from techniques to analyze the physical characteristics of collagen to methods to study collagen abundance and modifications. In this review, we illustrate the potential of mass spectrometry for in-depth analyses of collagen.

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Keywords collagen, mass spectrometry, post-translational modification, proteomics
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Series VSNU Open Access deal
Journal Mass Spectrometry Reviews
van Huizen, N.A, IJzermans, J.N.M, Burgers, P.C, & Luider, T.M. (2019). Collagen analysis with mass spectrometry. Mass Spectrometry Reviews. doi:10.1002/mas.21600