Purpose of review To summarize the differential diagnosis and diagnostic approach of sudden unresponsiveness with normal vital signs in various settings, including the ICU. Recent findings Sudden unresponsiveness may be either transient or persistent, and may result from primary brain diseases or nonstructural systemic conditions. Life-threatening causes should always be discriminated from those more benign. Regional epidemiology, for example regarding intoxications, and evolving therapeutic management, for example for ischemic stroke, should always be taken into account for optimal opportunity for rapid diagnosis and best management. Summary Sudden unresponsiveness with normal vital signs should trigger immediate and focused diagnostic evaluation to find or exclude those conditions requiring urgent, and possibly life-saving, management.

Additional Metadata
Keywords coma, emergency departments, ICU, neurological diagnostic technique
Persistent URL dx.doi.org/10.1097/MCC.0000000000000663, hdl.handle.net/1765/119735
Series VSNU Open Access deal
Journal Current Opinion in Critical Care
Smit, L. (Lisa), Foks, K.A. (Kelly A.), Hofmeijer, J, & van der Jagt, M. (2019). Sudden unresponsive patient with normal vital signs: What is going on?. Current Opinion in Critical Care. doi:10.1097/MCC.0000000000000663