Transcription factors have been traditionally studied at the level of transcription, neglecting a potential impact on protein translation. A new study published by Lorent et al (2019) describes a mechanism by which fluctuations in mRNA abundance are counteracted during translation upon estrogen receptor-alpha (ERα) depletion. This phenomenon, termed translational offsetting, is prevalent and programmed to maintain essential proteins at constant levels.

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Journal EMBO Journal
Note corresponding author at The Netherlands Cancer Institute, Amsterdam,
Kozlovski, I. (Itamar), & Agami, R. (2019). More or less – the same? mRNA fluctuations are balanced during translation. EMBO Journal. doi:10.15252/embj.2019103651