Prognostic significance of the controlling nutritional status (CONUT) score in patients with colorectal cancer
A systematic review and meta-analysis
Background: The clinical evidence of the controlling nutritional status (CONUT) score for outcomes has increased in gastroenterological surgical oncology. The aim of this study was to investigate the impact of the CONUT score on outcomes in patients with colorectal cancer (CRC).
Methods: A literature review was systematically conducted to evaluate the significance of the CONUT score in CRC patients. Meta-analyses of survival were performed to investigate the effects of the CONUT score in CRC patients.
Results: Nine studies met the inclusion criteria, and six studies with 2601 patients were included in the present meta-analyses. High CONUT score was associated with poor overall survival (HR 1.97, 95%CI = 1.40–2.77, P < 0.001), cancer-specific survival (HR 3.64, 95%CI = 1.96–6.75, P < 0.001), and recurrence/relapse-free survival (HR 1.68, 95%CI = 1.23–2.29, P = 0.001) after CRC surgery.
Conclusions: The CONUT score is a practical prognostic factor associated with prognosis of CRC. Further studies are needed to clarify the significance of the CONUT score in CRC patients.
|Keywords||Colorectal cancer, Controlling nutritional status (CONUT) score, Meta-analysis, Outcome|
|Persistent URL||dx.doi.org/10.1016/j.ijsu.2020.04.046, hdl.handle.net/1765/126498|
|Series||VSNU Open Access deal|
|Journal||International Journal of Surgery|
Takagi, K, Büttner, S, & IJzermans, J.N.M. (2020). Prognostic significance of the controlling nutritional status (CONUT) score in patients with colorectal cancer. International Journal of Surgery (Vol. 78, pp. 91–96). doi:10.1016/j.ijsu.2020.04.046