Synapses are specialized communication junctions between neurons whose plasticity provides the structural and functional basis for information processing and storage in the brain. Recent biochemical, genetic and imaging studies in diverse model systems are beginning to reveal the molecular mechanisms by which synaptic vesicles, ion channels, receptors and other synaptic components assemble to make a functional synapse. Recent evidence has shown that the formation and function of synapses are critically regulated by the liprin-α family of scaffolding proteins. The liprin-αs have been implicated in pre-and post-synaptic development by recruiting synaptic proteins and regulating synaptic cargo transport. Here, we will investigate the diversity of liprin binding partners, the factors that control the function of liprin-αs at the synapse, and how liprin-α family proteins regulate synapse formation and synaptic transmission.

Additional Metadata
Keywords axon, dendrite, liprin, neuron, synapse
Promotor C.I. de Zeeuw (Chris)
Publisher Erasmus University Rotterdam
Sponsor Netherlands Organization for Scientific Research (NWO),Netherlands Organization for Health Research and Development
Persistent URL
Spangler, S.A. (2009, November 18). Liprin-alpha Proteins Regulate Neuronal Development and Synapse Function. Erasmus University Rotterdam. Retrieved from

Additional Files
Introduction.pdf Final Version , 1mb
Discussion.pdf Final Version , 1mb
References.pdf Final Version , 252kb
Table of Contents.pdf Final Version , 188kb
Curriculum Vitae.pdf Final Version , 177kb
Summary.pdf Final Version , 130kb
Samenvatting.pdf Final Version , 130kb
Title Page.pdf Final Version , 127kb
Stellingen.pdf , 59kb
3003_Spangler, Samantha Ann.jpg Cover Image , 23kb