2012-07-01
Clinical value of circulating endothelial cell detection in oncology
Publication
Publication
Drug Discovery Today , Volume 17 - Issue 13-14 p. 710- 717
Given the importance of tumor vasculature in tumor biology and as a target for treatment, there is an increasing need for biomarkers that reflect effects impacting tumor vasculature accurately. Circulating endothelial cells (CECs) increase in number as a result of vascular damage in cancer and several other diseases. CEC count constitutes a promising tool for monitoring disease activity with potential to assess prognosis and response to treatment. Here, we address the current state-of-the-art of CEC enumeration as a biomarker in clinical oncology. We focus on technical issues concerning CEC detection, review results from clinical studies and explore future potential applications.
| Additional Metadata | |
|---|---|
| doi.org/10.1016/j.drudis.2012.01.011, hdl.handle.net/1765/57690 | |
| Drug Discovery Today | |
| Organisation | Department of Medical Oncology |
|
Kraan, J., Sleijfer, S., Foekens, J., & Gratama, J.-W. (2012). Clinical value of circulating endothelial cell detection in oncology. Drug Discovery Today (Vol. 17, pp. 710–717). doi:10.1016/j.drudis.2012.01.011 |
|