Background: Histamine is an indicator of mast cell activation. N- methylhistamine (NMH) is a metabolite of histamine that can be measured in urine. Objective: Our purpose was to assess the usefulness of determining urinary NMH levels for the diagnosis and follow-up of patients with mastocytosis. Methods: Urinary NMH levels were determined in 44 patients and were correlated with disease activity and extension. The control group consisted of 24 children without mastocytosis or any other skin disease. Results: A significant negative correlation was found between NMH and age in patients with active mastocytosis and in the control group. Adjusted for age, NMH values were significantly higher in patients with active mastocytosis. There was a significant difference in NMH values between patients with diffuse cutaneous mastocytosis, patients with active urticaria pigmentosa, and patients with active mastocytomas. However, there was a substantial overlap of NMH values in the different subgroups. Conclusion: Urinary NMH values tend to decrease with age. Urinary NMH values correlated with the extent and the activity of the disease. High NMH values suggest more extensive involvement.,
American Academy of Dermatology. Journal
Department of Dermatology

van Gysel, D, Oranje, A.P, Vermeiden, I, De Lijster De Raadt, J, Mulder, P.G.H, & van Toorenenbergen, A.W. (1996). Value of urinary N-methylhistamine measurements m childhood mastocytosis. American Academy of Dermatology. Journal, 35(4), 556–558. doi:10.1016/S0190-9622(96)90679-9