This thesis describes the relation between nutrition and cardiometabolic health, with the focus on nutritional exposures in pregnancy and early childhood. A systematic review of the literature was performed to describe the effects of the nutrients lutein and choline on cardiometabolic health across the life course. Within the Generation R Study, a population-based prospective cohort study in the Netherlands, dietary patterns during pregnancy were studied, in relation to offspring body composition and cardiometabolic health. The relation between nutrition in early childhood with body composition and cardiometabolic health at school-age was assessed using different kind of nutritional exposures, namely nutrients (lutein), food groups (sugar-containing beverages) and dietary patterns (a priori- and a posterioiri-derived dietary patterns).

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Keywords Lutein, choline, sugar-containing beverages, dietary patterns, diet score, systematic review, birth cohort studie, body composition, cardiometabolic health
Promotor O.H. Franco (Oscar) , V.W.V. Jaddoe (Vincent)
Publisher Erasmus University Rotterdam
Sponsor The work presented in this thesis was conducted within ErasmusAGE, department of Epidemiology, in close collaboration with the Generation R Study Group. ErasmusAGE is a centre for aging research across the life course funded by Nestlé Nutrition (Nestec Ltd.), Metagenics Inc. and AXA. Nestlé Nutrition (Nestec Ltd.), Metagenics Inc. and AXA had no role in design and conduct of the study, collection, management, analysis, and interpretation of the data; and preparation, review or approval of the manuscripts. The general design of the Generation R Study is made possible by financial support from the Erasmus Medical Centre, Rotterdam, the Erasmus University Rotterdam, the Netherlands Organization for Health Research and Development (ZonMw), the Netherlands Organisation for Scientific Research (NWO), the Ministry of Health, Welfare and Sport and the Ministry of Youth and Families. Publication of this thesis was kindly supported by the Department of Epidemiology, the Generation R Study Group and the Erasmus University Rotterdam. Financial support by the Dutch Heart Foundation is gratefully acknowledged. Additional financial support was generously provided by Nestlé Nutrition, the Netherlands Association for the Study on Obesity (NASO), and Verloskundigenpraktijk de Bron.
ISBN 978-94-6050-009-1
Persistent URL hdl.handle.net/1765/77768
Leermakers, E.T.M. (2015, May 13). Early-life Nutrition and Cardiometabolic Health across the Life Course. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/77768