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T.A. Knoch (Tobias), C. Münkel (Christian) and J. Langowski (Jörg)

1998-07-02

Three-dimensional organization of chromosome territories in the human interphase nucleus

Publication

Publication

Presented at the Supercomputing at the German Cancer Research Centre (DKFZ), German Cancer Research Centre (DKFZ) (July 1998), Heidelberg, Germany

The synthesis of proteins, maintenance of structure and duplication of the eukaryotic cell itself are all fine-tuned biochemical processes that depend on the precise structural arrangement of the cellular components. The regulation of genes – their transcription and replication - has been shown to be connected closely to the three-dimensional organization of the genome in the cell nucleus. Despite the successful linear sequencing of the human genome its three-dimensional structure is widely unknown.

Additional Metadata
Keywords Genome, genomics, genome organization, genome architecture, structural sequencing, architectural sequencing, systems genomics, coevolution, holistic genetics, genome mechanics, genome function, genetics, gene, regulation, replication, transcription, repair, homologous recombination, simultaneous co-transfection, cell, division, mitosis, metaphase, interphase, cell nucleus, nuclear structure, nuclear organization, chromatin density, distribution, nuclear morphology, chromosome territories, subchromosomal domains, chromatin loop, aggregates, chromatin rosettes, chromatin loops, chromatin fibre, chromatin density, persistence length, spatial, distance measurement, histones, H1.0, H2A, H2B, H3, H4, mH2A1.2, DNA sequence, complete sequenced, genomes, molecular transport, obstructed diffusion, anomalous diffusion, percolation, long-range correlations, fractal analysis, scaling analysis, exact yard-stick dimension, box-counting dimension, lacunarity dimension, local nuclear dimension, nuclear diffuseness, parallel super computing, grid computing, volunteer computing, Brownian Dynamics, Monte Carlo, fluorescence in situ hybridization, confocal laser scanning microscopy, fluorescence correlation spectroscopy, super resolution microscopy, spatial precision distance microscopy, autofluorescent proteins, CFP, GFP, YFP, DsRed, fusionprotein, in vivo labelling
Persistent URL hdl.handle.net/1765/78083
Conference Supercomputing at the German Cancer Research Centre (DKFZ), German Cancer Research Centre (DKFZ)
Organisation Biophysical Genomics, Department Cell Biology & Genetics
Citation
Knoch, T., Münkel, C., & Langowski, J. (1998, July 2). Three-dimensional organization of chromosome territories in the human interphase nucleus. Presented at the Supercomputing at the German Cancer Research Centre (DKFZ), German Cancer Research Centre (DKFZ). Retrieved from http://hdl.handle.net/1765/78083
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