Background: Keratinocyte cancer is the most common cancer among Caucasians. Objective: We sought to study time trends of the burden of disease attributable to keratinocyte cancer in The Netherlands. Methods: Data of all patients with newly diagnosed keratinocyte cancer (ie, squamous cell carcinoma and basal cell carcinoma) were obtained from the population-based Netherlands Cancer Registry and the Eindhoven Cancer Registry (1989-2008). Population structure, mortality data, and life expectancy data were extracted from Statistics Netherlands. The disability-adjusted life-years (DALY) was the sum of the years of life lived with disability and the years of life lost. Results: The world standardized rate of keratinocyte cancer has doubled and was 103 and 94 per 100,000 person-years for males and females in 2004 to 2008, respectively. DALYs as a result of basal cell carcinoma increased by 124% and DALYs as a result of squamous cell carcinoma increased by 66% from 1989 to 1993. Keratinocyte cancer accounted for a total loss of 19,913 DALYs (15,369 years of life lived with disability and 4544 years of life lost) between 2004 and 2008. Limitations: Only the first keratinocyte cancer was included in this study. Conclusion: Keratinocyte cancer is a large burden to the Dutch society. Because incidence rates of keratinocyte cancer continue to increase, the management becomes even more challenging.

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Keywords Basal cell carcinoma, Burden of disease, Cutaneous squamous cell carcinoma disability-adjusted life-year, Keratinocyte cancer, Population-based
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Journal American Academy of Dermatology. Journal
Hollestein, L.M, de Vries, E, Aarts, M.J, Schroten-Loef, C, & Nijsten, T.E.C. (2014). Burden of disease caused by keratinocyte cancer has increased in The Netherlands since 1989. American Academy of Dermatology. Journal, 71(5), 896–903. doi:10.1016/j.jaad.2014.07.003