Identification of Novel Prostate Cancer Biomarkers Using High-throughput Technologies

Prostate cancer is one of the most prevalent cancers in men and represents a severe burden on both patients and healthcare systems in western societies. To address the limitations of current risk stratification methods, the aim of this thesis was to identify novel biomarkers, such as RNA molecules that can discriminate PCa from non-cancerous conditions with high specificity and/or allow accurate prediction of disease outcome. Moreover, we aimed to advance next generation sequencing in clinical applications by addressing and simplifying some of the associated bioinformatics challenges.