In this thesis I studied COPD using several omics layers in attempt to elucidate the molecular mechanisms underlying the disease. I have identified several novel risk factors for COPD and its comorbidities, proposed regulatory pathways and highlighted the need for integration of the multi-omics data. Furthermore, I have discussed methodological challenges and ideas from which the future respiratory research could benefit.
Findings of this thesis require functional confirmation, but I am confident that it represents another important step on a path towards improved clinical care and prevention of COPD, based on precision medicine.

Additional Metadata
Keywords Chronic obstructive pulmonary disease, COPD, genetics, epigenetics, transcriptomics, metabolomics, lung disease, rare variants, multi-omics, integrative analysis, mendelian randomization, comorbidities, depression, asthma, cord blood
Promotor C.M. van Duijn (Cornelia) , N. Amin (Najaf)
Publisher Erasmus University Rotterdam
ISBN 978-94-6361-290-6
Persistent URL
Prokić, I. (2019, September 4). Multi-Omics Study of Chronic Obstructive Pulmonary Disease and Related Disorders. Erasmus University Rotterdam. Retrieved from