In this thesis I studied COPD using several omics layers in attempt to elucidate the molecular mechanisms underlying the disease. I have identified several novel risk factors for COPD and its comorbidities, proposed regulatory pathways and highlighted the need for integration of the multi-omics data.
Furthermore, I have discussed methodological challenges and ideas from which the future respiratory research could benefit.
Findings of this thesis require functional confirmation, but I am confident that it represents another important step on a path towards improved clinical care and prevention of COPD, based on precision medicine.

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C.M. van Duijn (Cornelia) , N. Amin (Najaf)
Erasmus University Rotterdam
Department of Epidemiology

Prokić, I. (2019, September 4). Multi-Omics Study of Chronic Obstructive Pulmonary Disease and Related Disorders. Retrieved from