2019-09-04
Multi-Omics Study of Chronic Obstructive Pulmonary Disease and Related Disorders
Publication
Publication
Multi-omics studie van Chronische Obstructieve Longziekte en verwante stoornissen
In this thesis I studied COPD using several omics layers in attempt to elucidate the molecular mechanisms underlying the disease. I have identified several novel risk factors for COPD and its comorbidities, proposed regulatory pathways and highlighted the need for integration of the multi-omics data.
Furthermore, I have discussed methodological challenges and ideas from which the future respiratory research could benefit.
Findings of this thesis require functional confirmation, but I am confident that it represents another important step on a path towards improved clinical care and prevention of COPD, based on precision medicine.
| Additional Metadata | |
|---|---|
| , , , , , , , , , , , , , , | |
| C.M. van Duijn (Cornelia) , N. Amin (Najaf) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/118758 | |
| Organisation | Department of Epidemiology |
|
Prokić, I. (2019, September 4). Multi-Omics Study of Chronic Obstructive Pulmonary Disease and Related Disorders. Retrieved from http://hdl.handle.net/1765/118758 |
|
| Additional Files | |
|---|---|
| Cover-Prokic.PNG Cover Image , 2mb | |
| -8539-ivanaprokic-propositionsv3.pdf , 556kb | |
| 118758_Chapter_1-Introduction.pdf Final Version , 1mb | |
| 118758_Chapter_2_1-A_genome-wide_linkage_study_for_chroni.pdf Final Version , 1mb | |
| 118758_Chapter_2_2-Understanding_the_role_of_the_chromoso.pdf Final Version , 1mb | |
| 118758_Chapter_2_3-COPD_GWAS_variant_at_19q13_2_in_relati.pdf Final Version , 1mb | |
| 118758_Chapter_2_4-DNA_methylation_is_associated_with_lun.pdf Final Version , 1mb | |
| 118758_Chapter_3_1-New-born_DNA-methylation-_childhood_lu.pdf Final Version , 1mb | |
| 118758_Chapter_3_2-A_cross-omics_integrative_study_of_met.pdf Final Version , 1mb | |
| 118758_Chapter_3_3-Genetic_correlation_of_Chronic_Obstruc.pdf Final Version , 886kb | |
| 118758_Chapter_3_4-DNA_methylation_signatures_of_depressi.pdf Final Version , 1mb | |
| 118758_Chapter_4-General_discussion.pdf Final Version , 1mb | |
| 118758_Chapter_5-Summary_Samenvatting.pdf Final Version , 735kb | |
| 118758_Chapter_6-Appendix.pdf Final Version , 892kb | |
