The aims of this thesis are to study the development of transcatheter aortic valve implantation (TAVI), including pre-procedural imaging, novel adaptations and failure of the technology, and to draw on these experiences to explore some basic principles of transcatheter mitral valve implantation (TMVI).

Specific goals include:
1. To review the anatomy of the aortic valve complex, principles of patient selection, and key procedural steps in TAVI.
2. To investigate the importance of non-invasive imaging in TAVI, with specific focus on pre-procedural multislice computed tomography.
3. To appraise the prevalence of aortic stenosis and adoption of TAVI in Europe.
4. To assess clinical outcomes associated with novel adaptations of TAVI technology.
5. To apply knowledge gained from the aortic valve arena, and apply it to describe a standardized methodology for the assessment of the mitral valve complex using multislice computed tomography for the purposes of transcatheter mitral valve implantation.

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A.P. Kappetein (Arie Pieter) , N. Piazza (Nicolo)
Erasmus University Rotterdam
Department of Cardio-Thoracic Surgery

Mylotte, D. (2019, January 15). Evolution of Transcatheter Heart Valve Technology: Refining Aortic and Defining Mitral Valve Implantation. Retrieved from

Additional Files
PhD-Propositions-DM.pdf , 92kb
112894_Chapter_1-General_Introduction-_Aims-_and_Outline.pdf Final Version , 299kb
112894_Chapter_2-The_Anatomy_of_the_Aortic_Valvar_Complex.pdf Final Version , 33mb
112894_Chapter_3-Patient_selection_for_transcatheter_aort.pdf Final Version , 864kb
112894_Chapter_4-Transfemoral_Transcatheter_Aortic_Valve.pdf Final Version , 8mb
112894_Chapter_5-Erroneous_measurement_of_the_aortic_annu.pdf Final Version , 3mb
112894_Chapter_6-Aortic_stenosis_in_the_elderly.pdf Final Version , 2mb
112894_Chapter_7-Transcatheter_aortic_valve_replacement_i.pdf Final Version , 2mb
112894_Chapter_8-Introduction_of_Objective_Performance_Cr.pdf Final Version , 682kb
112894_Chapter_9-Transcatheter_heart_valve_implantation_f.pdf Final Version , 5mb
112894_Chapter_10-Failing_surgical_bioprosthesis_in_aorti.pdf Final Version , 2mb
112894_Chapter_11-TAVI_for_Failing_Surgical_Aortic_Biopro.pdf Final Version , 4mb
112894_Chapter_12-Transcatheter_Aortic_Valve_Implantation.pdf Final Version , 291kb
112894_Chapter_13-Transcatheter_aortic_valve_replacement.pdf Final Version , 2mb
112894_Chapter_14-Novel_TAVI_Systems.pdf Final Version , 6mb
112894_Chapter_15-Transcarotid_TAVI.pdf Final Version , 4mb
112894_Chapter_16-TAVI_Failure.pdf Final Version , 1mb
112894_Chapter_17-Transcatheter_mitral_valve_implantation.pdf Final Version , 3mb
112894_Chapter_18-Quantitative_multi-slice_computed_tomog.pdf Final Version , 13mb
112894_Chapter_19-Quantitative_multi-slice_computed_tomog.pdf Final Version , 2mb
112894_Chapter_20-Summary.pdf Final Version , 178kb
112894_Chapter_21-General_Discussion.pdf Final Version , 229kb
112894_Chapter_23-List_of_publications.pdf Final Version , 196kb
112894_Chapter_24-PhD-Portfolio.pdf Final Version , 169kb
112894_Chapter_25-Dankwoord_Acknowledgements.pdf Final Version , 175kb
112894_Chapter_26-About_the_author.pdf Final Version , 161kb